Question 22

(Multiple Choice)

Which of the following statements about excision repair is correct?


A) Base excision repair is initiated by DNA glycosylases that recognize abnormal deoxyriboses in DNA
B) Nucleotide excision repair removes large regions of DNA via an exonuclease which cuts on either side of the damaged bases
C) E. coli exonuclease activity is carried out by uvrA, uvrB, and uvrC, and the resulting gap is filled in by DNA Pol III
D) DNA glycosylases cleave the altered nucleoside (base and sugar) from the DNA backbone creating an apurinic or apyrimidinic site
E) In humans, a mechanism similar to E. coli is carried out where the protein XPA acts as the exonuclease.

Answer