The Basic Principle in Duplication Mapping is That

Question

The basic principle in duplication mapping is that:
A) A duplication that covers a recessive mutation must contain a wild-type copy of the mutant gene
B) A duplication that uncovers a recessive mutation must contain a wild type copy of the mutant gene
C) A duplication that covers a recessive mutation must contain the recessive mutation of the gene
D) A duplication that uncovers a recessive mutation must lack a wild type copy of the mutant gene
E) A duplication that covers the recessive mutation must lack a wild type copy of the mutant gene

Accepted Answer

A duplication that covers a recessive mutation must contain a wild-type copy of the mutant gene to complement the recessive mutation and restore the wild-type phenotype.