The Sex-Linked Disease Called Testicular Feminization,if Transferred from Mother to Son,forms

Question

The sex-linked disease called testicular feminization,if transferred from mother to son,forms:
A) males (XY) that are phenotypically female and sterile.
B) females (XY) that are sterile.
C) males (XY) that are sterile.
D) females (XY) that are phenotypically male and are sterile.
E) fertile males (XY)

Accepted Answer

Testicular feminization is caused by a mutation in the gene for the androgen receptor, which leads to the inability of cells to respond to testosterone. As a result, XY individuals with this condition have male internal organs but female external genitalia and secondary sex characteristics. They are typically raised as females, but they are sterile because they lack ovaries and have testes that do not produce sperm. If the condition is inherited from a mother who is a carrier, there is a 50% chance that her sons will inherit the mutation and develop testicular feminization. These sons will be phenotypically female but genetically male, and they will be sterile.