Class II MHC Genes Code For

Question

Class II MHC genes code for
A)certain secreted complement components.
B)self receptors recognized by natural killer cells.
C)all HLA antigens.
D)receptors located primarily on macrophages, dendritic cells, and B cells.
E)All of these choices are correct.

Accepted Answer

Class II MHC genes code for receptors located primarily on macrophages, dendritic cells, and B cells. They are involved in presenting antigens to CD4+ T cells for initiation of the adaptive immune response. Class I MHC genes code for self receptors recognized by natural killer cells, and HLA antigens are a subset of Class I and Class II MHC antigens that vary between individuals and determine tissue compatibility for transplantation. Secreted complement components are not coded for by MHC genes.