What is the sequence of events to produce a protein that is secreted?

A) A hormone signals the gene that encodes the protein to be transcribed into mRNA in the nucleus. The mRNA is translated into protein on the ER, then processed and folded in the Golgi apparatus, and then sent out of the cell in a vesicle.
B) A hormone signals a protein-filled vesicle to move from the plasma membrane into the cell and into the nucleus, where it stimulates transcription of the appropriate gene into mRNA. The mRNA exits the nucleus and is translated into protein on the ER and processed and folded in the Golgi apparatus. Finally, the protein is transported out of the cell in a vesicle.
C) A hormone binds to the plasma membrane, signaling proteins near the membrane to fall apart into amino acids. These enter the nucleus and stimulate replication of the gene encoding the protein.
D) The protein is produced as a linear molecule in the nucleus, then exits through nuclear pores. On the ER the protein folds into its active form and at the Golgi apparatus is packed into a vesicle, which carries it across the plasma membrane and out of the cell.
E) A hormone signals the gene that encodes the protein to be transcribed into mRNA in the nucleus, and translated into protein on the ER and processed and folded in the Golgi apparatus. The protein travels freely through the plasma membrane to exit the cell.