Which maternal serum marker pattern indicates increased risk of Down syndrome in a fetus?

A) deficient hCG and inhibin A and elevated AFP, estriol, and pregnancy-associated plasma protein A Progesterone and testosterone
B) elevated hCG, inhibin A, AFP, estriol, and pregnancy-associated plasma protein
C) deficient hCG, inhibin A, AFP, estriol, and pregnancy-associated plasma protein
D) elevated hCG and inhibin A and deficient AFP, estriol, and pregnancy-associated plasma protein A
E) elevated cholesterol and presenilin 1 and deficient insulin