Chronic Myeloid Leukemia is Caused by a Translocation That Creates

Question

Chronic myeloid leukemia is caused by a translocation that creates
A) a proto-oncogene.
B) a fusion protein that acts like a transcription factor, activating cell cycle control genes.
C) a protein that increases growth factor production.
D) a fusion protein that deregulates the cell cycle of myeloid white blood cells.
E) a deletion of a whole chromosome.

Accepted Answer

Chronic myeloid leukemia is caused by the Philadelphia chromosome, a result of a translocation between chromosomes 9 and 22, creating the BCR-ABL fusion protein. This protein deregulates the cell cycle of myeloid white blood cells, leading to uncontrolled proliferation.