Question 2

(Multiple Choice)

Familial hypercholesterolemia is a genetic disease that affects approximately one in 500 people worldwide.There is more than one genetic cause of the disease.Class I is often described as an autosomal dominant disease.Affected individuals have cholesterol levels >250 as children and often >300 as adults.However,homozygotes have cholesterol levels of >600 as children and can die of heart attacks in their 20s.These individuals entirely lack a functional LDL receptor.Which of the following would be the best description of the inheritance of this form of hypercholesterolemia?


A)Dominant epistatic
B)Codominant
C)Incompletely dominant
D)Complementary
E)Recessive epistatic

Answer

C