A Person with Sickle-Cell Trait Has ________ at the β-Globin

Question

A person with sickle-cell trait has ________ at the β-globin locus.
A)two wild-type alleles
B)two mutant alleles
C)one wild-type and one mutant allele
D)one wild-type and one deleted allele
E)one mutant and one deleted allele

Accepted Answer

A person with sickle-cell trait has one wild-type and one mutant allele at the β-globin locus. The mutation in sickle-cell trait is a single nucleotide change in the HBB gene, resulting in the substitution of valine for glutamic acid at position 6 of the β-globin chain. This mutation is inherited in an autosomal co-dominant pattern, meaning that individuals with sickle-cell trait have one copy of the mutant allele and one copy of the wild-type allele.