The major difference in gene regulation between prokaryotes and eukaryotes is

A)eukaryotic and prokaryotic genes are usually grouped for common functions.
B)eukaryotic genes regulation requires fewer signals than prokaryotic gene regulation.
C)eukaryotic gene regulation is more simplistic than prokaryotic gene regulation.
D)eukaryotic genes are arranged individually,while prokaryotic genes are grouped into operons.
E)eukaryotic gene regulation tends to require less coordination and integration than prokaryotic gene regulation.