All epithelial cells in the inner lining of the large intestine that are heterozygous for an APC mutation ____.

A) are able to control cell division with the second copy of the APC gene
B) become cancerous
C) require additional mutations in downstream genes to become cancerous
D) cause the transition from polyps into colon cancer
E) can partially escape control of the cell cycle and lead to the formation of clusters of polyps