The Translocation Seen in the Philadelphia Chromosome in Myelogenous Leukemia

Question

The translocation seen in the Philadelphia chromosome in myelogenous leukemia represents ____.
A) a chromosomal aberration that is secondary to the cancer
B) a chromosomal aberration that is caused by the development of cancer
C) a proto-oncogene that has been deleted from chromosome 6 and inserted into chromosome 7
D) a specific chromosomal aberration accompanying a specific cancer
E) the evidence of exposure to chemical carcinogens

Accepted Answer

The translocation seen in the Philadelphia chromosome in myelogenous leukemia is a specific chromosomal aberration accompanying a specific cancer. It involves the reciprocal translocation between chromosomes 9 and 22, resulting in the fusion of the BCR and ABL genes, which leads to the formation of the BCR-ABL fusion gene. This mutation contributes to the development and progression of the disease.