Genetic Goitrous Cretinism and Alkaptonuria are Metabolic Disorders in the ____

Question

Genetic goitrous cretinism and alkaptonuria are metabolic disorders in the ____ pathway.
A) nucleic acid
B) thalassemia
C) phenylalanine
D) paraoxonase
E) lipid biochemical

Accepted Answer

Genetic goitrous cretinism and alkaptonuria are both metabolic disorders in the phenylalanine pathway. In genetic goitrous cretinism, there is a deficiency in the enzyme thyroxine peroxidase, which results in a decrease in the production of thyroid hormones and leads to goiter and mental retardation. Alkaptonuria is caused by a deficiency in homogentisate oxidase, an enzyme in the phenylalanine pathway, which results in the accumulation of homogentisic acid and leads to osteoarthritis and black urine.