Explain why only one in three attempts at somatic recombination results in a productive VJ or VDJ combination.

The final steps in somatic recombination involve ligation of the coded regions.This step is imprecise.Whenever V > J,D > J,or V > DJ elements recombine,the resulting reading frame is random.Only one in three attempts will result in a reading frame that is compatible with either heavy-chain or light-chain synthesis.