What are the biochemical activities of Wee1 and Cdc25 proteins? How do these activities regulate MPF?
Answer
Wee1 is a kinase that phosphorylates Cdc2 on Tyr-15 and inhibits its activity.Cdc25 is a phosphatase that removes this phosphate and re-establishes activity in the presence of a phosphate group on Thr-161 in Cdc2.