Gelsolin is Activated By

Question

Gelsolin is activated by:
A)ATP binding.
B)phosphorylation.
C)Ca²⁺ binding.
D)dephosphorylation.

Accepted Answer

Gelsolin is known to be activated by Ca²⁺ binding, which induces a conformational change that leads to its activation. This activation allows gelsolin to break down actin filaments, enabling cellular processes such as cytokinesis and motility. While ATP binding and phosphorylation are important processes in cellular signaling, they do not directly activate gelsolin. Dephosphorylation can inactivate some proteins but is not known to activate gelsolin specifically. Therefore, the best choice is C, Ca²⁺ binding.