Latent TGFβ is Converted to Mature TGFβ By

Question

Latent TGFβ is converted to mature TGFβ by:
A)dephosphorylation.
B)phosphorylation.
C)proteolysis.
D)translocation.
E)none of the above

Accepted Answer

Latent TGFβ is initially produced and secreted in its inactive form, which is composed of a homodimer of TGFβ bound to latency-associated peptide (LAP). To activate TGFβ, LAP must be cleaved off, which is accomplished by proteolysis. This releases the mature, biologically active form of TGFβ.