What is the Advantage of Using a Cold-Adapted Strain of Influenza

Question

What is the advantage of using a cold-adapted strain of influenza A as a vaccine?
A) It spreads between people better than the wild-type.
B) It does not replicate well in the lung tissue.
C) It does not stimulate the release of interferon.
D) It does not cause as much cell damage as the wild-type virus.
E) It is more immunogenic than the wild-type.

Accepted Answer

Cold-adapted strains are designed to replicate efficiently at cooler temperatures, such as those found in the upper respiratory tract, but not at the warmer temperatures of the lungs, reducing the risk of causing disease.