Many viruses reduce the amount of MHC-I complex on the surface of the infected cell.How does the immune system recognize cells that lack MHC-I?

A) Cytotoxic T lymphocytes will recognize the lack of MHC-I on the surface and kill the cell
B) Macrophages will recognize an antibody bound to MHC-I and engulf the cell.
C) Natural killer cells will kill cells that lack MHC-I on their surface.
D) Cells that don't have enough MHC-I on their surface will enter apoptosis and die.
E) Cytotoxic T lymphocytes will recognized the altered MHC-I on the cell surface.