Which of the following observations about the PrPˢᶜ protein could explain how this protein causes damage to the neurons of the brain?

A) The PrPˢᶜ protein causes glycosylation of membrane proteins to become disregulated.
B) The PrPˢᶜ protein causes copper to be sequestered in neurons.
C) The PrPˢᶜ protein is more resistant to protease digestion than the cellular form.
D) The PrPˢᶜ protein alters the signaling pathways in neurons.
E) The PrPˢᶜ protein aggregates to form fibrils.