Which of the following describes the mechanism used by the E6 protein of papillomaviruses to remove the p53 protein.

A) It causes the p53 protein to be exported out of the cell.
B) It causes the p53 protein to be targeted to the lysosome.
C) It causes the p53 protein to become ubiquinated.
D) It acts as a protease to directly degrade the protein.
E) It phosphorylates p53, which causes it to be degraded by the proteasome.