When the late promoter of papillomaviruses is activated, it increases production of the E1 and E2 proteins.Which of the following explains why an increase in these two proteins would contribute to vegetative replication of the virus?

A) They repress transcription for the early promoter.
B) They can cause the keratinocytes to become differentiated.
C) They initiate DNA replication of the viral genome.
D) They interact with the cellular protein pRb.
E) They interact with the cellular protein p53