SV40 Will Only Transform Cells Which are Nonpermissive for Productive

Question

SV40 will only transform cells which are nonpermissive for productive viral infection.

Accepted Answer

SV40 can only transform cells which are not permissive for a productive viral infection, meaning that the virus cannot replicate and produce new virus particles within the cell. This is because the virus requires cellular machinery to replicate, but these nonpermissive cells lack the necessary receptors or signaling pathways for viral entry and replication. However, SV40 can still enter and interact with these cells to induce oncogenic transformation, leading to uncontrolled cell growth and tumor formation.