The Large T Antigen from SV40 Can Bind to All

Question

The large T antigen from SV40 can bind to all of the following cellular proteins EXCEPT….
A) Poly(A) polymerase
B) DNA polymerase a
C) p53
D) pRb
E) p300

Accepted Answer

The large T antigen from SV40 is known to bind to a wide range of cellular proteins as part of its function in promoting viral replication. This includes DNA polymerase a, p53, pRb and p300. However, there is no known interaction between the large T antigen and Poly(A) polymerase. Therefore, the correct answer is A) Poly(A) polymerase.