Enveloped Virions Assemble and Acquire Their Envelope by Which of the Following

Question

Enveloped virions assemble and acquire their envelope by which of the following mechanisms?
A) The nucleocapsids interact directly with the cytoplasmic tails of the envelope glycoproteins and bud through the cellular membrane.
B) The nucleocapsids interact with the matrix protein, which interact with the cytoplasmic tails of the envelope glycoprotein, and the virion buds through the cellular membrane.
C) The envelope is assembled de novo around the nucleocapsid by cellular enzymes.
D) The virion acquires the envelope after it leaves the host cell from extracellular vesicles.
E) Both a and b are used by viruses.

Accepted Answer

Enveloped virions can acquire their envelope through direct interaction of the nucleocapsids with the cytoplasmic tails of the envelope glycoproteins (A) or through an interaction mediated by the matrix protein between the nucleocapsids and the envelope glycoproteins (B). Both mechanisms involve budding through the cellular membrane.