What Chromosomal Change(s)can Lead to Birth Defects

Question

What chromosomal change(s)can lead to birth defects?
A) additional copies of chromosomes
B) aneuploidy
C) duplications of segments of chromosomes
D) deletions of segments of chromosomes
E) All of these can lead to birth defects.

Accepted Answer

All of the listed chromosomal changes can lead to birth defects. Additional copies or missing copies of a chromosome can disrupt normal development and cause conditions such as Down syndrome, while duplications and deletions of chromosome segments can also lead to abnormalities in gene expression and development. Aneuploidy, which refers to any abnormal number of chromosomes, can also lead to birth defects.