What is a Main Difference Between the Modes of Action of Peptide

Question

What is a main difference between the modes of action of peptide hormones and steroid hormones?
A)Peptide hormones bind to intracellular receptors,whereas steroid hormones bind to receptors on the cell surface.
B)Peptide hormones act as second messengers,whereas steroid hormones bind to receptors in the cytosol.
C)Peptide hormones bind to receptors on the cell surface,whereas steroid hormones act as second messengers.
D)Peptide hormones bind to receptors on the cell surface,whereas steroid hormones bind to intracellular receptors.
E)There are no differences;both act by binding to intracellular receptors.

Accepted Answer

The main difference between peptide hormones and steroid hormones is that peptide hormones bind to receptors on the cell surface, while steroid hormones bind to intracellular receptors. Peptide hormones cannot pass through the cell membrane and therefore must bind to specific receptors on the surface of the cell to initiate their signaling pathways. In contrast, steroid hormones are lipid-soluble and can easily pass through the cell membrane to bind to intracellular receptors such as those in the cytoplasm or nucleus.