Peptide Hormones (Chains of 50 or Fewer Amino Acids)are First

Question

Peptide hormones (chains of 50 or fewer amino acids)are first synthesized as
A)the hormone itself.
B)prehormones.
C)prohormones.
D)preprohormones.

Accepted Answer

Peptide hormones are first synthesized as preprohormones, which are larger precursor molecules that contain a signal sequence that directs the hormone to the endoplasmic reticulum for processing. In the endoplasmic reticulum, the signal sequence is removed and the preprohormone is cleaved to form the prohormone. The prohormone is then transported to the Golgi apparatus, where it is further processed to form the active hormone.