Which of These Factors Contributes to the Resistance of SJL/J

Question

Which of these factors contributes to the resistance of SJL/J mice to murine hepatitis virus?
A)Host cell receptor variability
B)Immune system defects
C)Pathogen strain variability
D)Anatomical anomalies
E)All are equally confounding

Accepted Answer

Host cell receptor variability is a factor that contributes to the resistance of SJL/J mice to murine hepatitis virus. Studies have shown that the receptor for murine hepatitis virus is different in SJL/J mice compared to susceptible strains, which may play a role in their resistance to infection. Immune system defects or anatomical anomalies have not been linked to resistance to this virus, and while pathogen strain variability can impact susceptibility, it is not the primary factor in this case.