All of the Following Lead to Drug-Induced Thrombocytopenic Purpura

Question

All of the following lead to drug-induced thrombocytopenic purpura.Which occurs first?
A)Antibodies and complement react with platelets.
B)Antibodies against haptens are formed.
C)Drug binds to platelets.
D)Platelets are destroyed.
E)Purpura occurs on the skin.

Accepted Answer

Drug-induced thrombocytopenic purpura occurs when a drug binds to platelets, forming complexes that are recognized as foreign by the immune system. This triggers the production of antibodies that attack and destroy the platelets, leading to thrombocytopenia (low platelet count) and purpura (small reddish-purple spots on the skin). The other options listed are potential consequences or events that occur as a result of drug-induced thrombocytopenic purpura, but drug binding to platelets is the initial trigger.