A Drug That Inhibits Angiotensin Converting Enzyme (ACE) May Lead

Question

A drug that inhibits angiotensin converting enzyme (ACE) may lead to all of the following except
A) less secretion of aldosterone.
B) increased urinary loss of sodium.
C) reduction of blood pressure.
D) decreased sodium reabsorption.
E) increased fluid retention.

Accepted Answer

Inhibition of ACE leads to decreased production of angiotensin II, which causes less secretion of aldosterone, decreased sodium reabsorption, and increased urinary loss of sodium. These effects ultimately lead to a reduction in blood pressure. However, inhibition of ACE may also lead to increased levels of bradykinin, a vasodilator, which can cause increased fluid retention. Therefore, the only option that is not a potential direct effect of ACE inhibition is E - increased fluid retention.