The Conversion of Fibrinogen to Fibrin is Catalyzed by the Enzyme

Question

The conversion of fibrinogen to fibrin is catalyzed by the enzyme
A) fibrinogen-converting enzyme.
B) plasmin.
C) factor VIII.
D) thrombin.
E) prothrombinase.

Accepted Answer

The conversion of fibrinogen to fibrin is catalyzed by the enzyme thrombin. Thrombin is produced by the activation of prothrombin by factor Xa, which is generated by the activation of factor X by either the extrinsic or intrinsic pathway of the coagulation cascade. Thrombin cleaves fibrinogen to form fibrin monomers, which polymerize to form a fibrin clot.