The Common Pathway of Coagulation Begins with The

Question

The common pathway of coagulation begins with the
A) sticking of platelets to damaged tissue.
B) activation of a proenzyme exposed to collagen.
C) release of tissue factor by damaged endothelium.
D) activation of Factor X and production of prothrombin activator.
E) conversion of fibrinogen to fibrin.

Accepted Answer

The common pathway of coagulation begins with activation of Factor X and production of prothrombin activator. This leads to the conversion of prothrombin to thrombin, which ultimately results in the conversion of fibrinogen to fibrin, leading to the formation of a blood clot. Sticking of platelets to damaged tissue (choice A) and activation of a proenzyme exposed to collagen (choice B) are part of the earlier steps in the coagulation cascade, while release of tissue factor by damaged endothelium (choice C) is part of the extrinsic pathway of coagulation.