Most of the Protein Factors That are Required for Clotting

Question

Most of the protein factors that are required for clotting are synthesized by
A) platelets.
B) megakaryocytes.
C) the liver.
D) the kidneys.
E) the spleen.

Accepted Answer

Most of the protein factors required for clotting are synthesized by the liver. The liver produces proteins including fibrinogen, prothrombin, and clotting factors I, II, V, VII, IX, XI, and XIII. Platelets and megakaryocytes play a role in clotting by aggregating and releasing factors, but they do not synthesize the majority of the necessary proteins. The kidneys and spleen do not have a significant role in clotting.