One Cause for Insulin Resistance in Non-Insulin Dependent (Type II)

Question

One cause for insulin resistance in non-insulin dependent (Type II) diabetes is
A) insulin receptor up-regulation.
B) decreased insulin secretion.
C) decreased cortisol secretion.
D) insulin receptor down-regulation.
E) cortisol receptor up-regulation.

Accepted Answer

Insulin resistance in Type II diabetes often occurs due to down-regulation of insulin receptors, which decreases the ability of insulin to effectively signal glucose uptake by cells. This leads to elevated blood glucose levels, which can further exacerbate insulin resistance.