Which Neurotransmitter Has a Direct Effect on Opening Chloride Channels

Question

Which neurotransmitter has a direct effect on opening chloride channels?
A) dopamine
B) norepinephrine
C) serotonin
D) GABA
E) endorphins

Accepted Answer

GABA (gamma-aminobutyric acid) is known as the primary inhibitory neurotransmitter in the central nervous system, and its binding to GABA receptors in neurons opens chloride channels, which hyperpolarizes the cell and makes it less likely to generate an action potential. This inhibitory effect of GABA plays a crucial role in reducing neuronal activity and controlling the excitability of neural circuits.