How Would the Loss of Acetylcholinesterase from the Motor End

Question

How would the loss of acetylcholinesterase from the motor end plate affect skeletal muscle?
A) It would make the muscles less excitable.
B) It would produce muscle weakness.
C) It would cause muscles to stay contracted.
D) It would cause muscles to stay relaxed.
E) It would have little effect on skeletal muscles.

Accepted Answer

Acetylcholinesterase breaks down acetylcholine in the synaptic cleft, which is necessary to end the muscle contraction signal. Without acetylcholinesterase, acetylcholine would not be degraded, leading to prolonged muscle contraction.