Which of the Following are Responsible for Alzheimer's Disease

Question

Which of the following are responsible for Alzheimer's disease?
A)polyglutamine aggregates
B)neurofibrillary tangles of polymeric microtubule-binding protein tau
C)extracellular deposits of amyloid-b and intracellular neurofibrillary tangles of microtubule-binding protein tau
D)mutations in the huntingtin gene

Accepted Answer

Extracellular deposits of amyloid-b and intracellular neurofibrillary tangles of microtubule-binding protein tau are the main pathological features of Alzheimer's disease. Polyglutamine aggregates are seen in Huntington's disease, and mutations in the huntingtin gene cause this disease. Neurofibrillary tangles of polymeric microtubule-binding protein tau are seen in other neurodegenerative diseases like frontotemporal dementia.