Which of the Following Compounds are Inhibitors of Purine and Pyrimidine

Question

Which of the following compounds are inhibitors of purine and pyrimidine biosynthesis?
A)eicosanoids and aspirin
B)NSAIDs and antibiotics
C)anticancer drugs and antibiotics
D)antibiotics and eicosanoids

Accepted Answer

Anticancer drugs such as methotrexate and 5-fluorouracil are inhibitors of purine and pyrimidine biosynthesis. Antibiotics such as trimethoprim and sulfamethoxazole are also inhibitors of the same pathways. Therefore, option C is the correct choice. Eicosanoids and aspirin are not inhibitors of purine and pyrimidine biosynthesis. NSAIDs such as aspirin and ibuprofen may inhibit the enzymes involved in prostaglandin biosynthesis, but they do not inhibit purine and pyrimidine biosynthesis directly.