How Many ATP and GTP Combined are Required in Gluconeogenesis

Question

How many ATP and GTP combined are required in gluconeogenesis for 2 pyruvate glucose?
A)4
B)5
C)6
D)7

Accepted Answer

For each molecule of pyruvate converted to glucose, 4 ATP and 2 GTP are required. Therefore, for 2 pyruvate molecules, 8 ATP and 4 GTP are required, which when combined total up to 12 nucleotides. However, during the process of gluconeogenesis, 2 ATP molecules are actually generated, so the net requirement for ATP and GTP is only 6. Therefore, the correct answer is C) 6.