Which Enzyme is Analogous to the Multi-Enzyme Complex α-Ketoglutarate

Question

Which enzyme is analogous to the multi-enzyme complex α-ketoglutarate?
A)glyceraldehyde-3-phosphate dehydrogenase
B)isocitrate dehydrogenase
C)pyruvate dehydrogenase
D)lactate dehydrogenase

Accepted Answer

Pyruvate dehydrogenase is analogous to the multi-enzyme complex α-ketoglutarate dehydrogenase, as both are involved in the citric acid cycle and catalyze similar decarboxylation reactions, converting their respective substrates into acetyl-CoA and succinyl-CoA, respectively.