Which of the Following is NOT Part of the 2-Step

Question

Which of the following is NOT part of the 2-step reaction catalyzed by isocitrate dehydrogenase?
A)?-decarboxylation expelling the a-keto carboxyl as CO?
B)oxidation of the C-2 alcohol of isocitrate to form oxalosuccinate
C)oxidation of the C-2 alcohol to form oxaloacetate
D)?-decarboxylation expelling the central carboxyl group as CO?

Accepted Answer

The 2-step reaction catalyzed by isocitrate dehydrogenase involves the oxidation of the C-2 alcohol of isocitrate to form oxalosuccinate and then the decarboxylation of oxalosuccinate to form alpha-ketoglutarate with the expulsion of CO₂. Option B describes the first step of the reaction, which is part of the process.