Which Enzymes of the TCA Cycle Catalyze Oxidative Decarboxylation Reactions

Question

Which enzymes of the TCA cycle catalyze oxidative decarboxylation reactions?
A)malate dehydrogenase and citrate synthase
B)fumarase and succinate dehydrogenase
C)α-ketoglutarate dehydrogenase and succinate dehydrogenase
D)isocitrate dehydrogenase and α-ketoglutarate dehydrogenase

Accepted Answer

Isocitrate dehydrogenase and α-ketoglutarate dehydrogenase are the enzymes in the TCA cycle that catalyze oxidative decarboxylation reactions, where a carbon atom is removed from the substrate in the form of carbon dioxide (CO2) while the substrate is oxidized.