Which of the Following Molecules Activates PDH Kinase

Question

Which of the following molecules activates PDH kinase?
A)ADP
B)calcium
C)NADH
D)insulin

Accepted Answer

NADH is an indicator of high energy levels in the cell and activates PDH kinase, which in turn inhibits the activity of pyruvate dehydrogenase complex (PDC). This allows the cell to conserve energy by preventing the breakdown of glucose into acetyl-CoA when there is already sufficient energy available. ADP, calcium, and insulin do not activate PDH kinase.