Which of the following attributes does NOT explain why enzymes are flexible proteins and NOT rigid molecules?

A)Active sites are able to conform to the shape of the substrate.
B)Strain is placed upon the substrate while it binds to the enzyme.
C)Catalytic residues are oriented in such a way that they play a minor role in bond breakage and bond formation.
D)Near-attack conformations are achieved during formation of the transition state during an enzyme-catalyzed reaction.