Which of the Following is a Feature of Transition-State Analogs

Question

Which of the following is a feature of transition-state analogs?
A)They are approximations of the transition state that bind less tightly than the substrate.
B)They are compounds that compete for the active site and are always very similar to the substrate.
C)They are stable molecules that are chemically and structurally similar to the transition state.
D)They are stable molecules that can be expected to resemble the true transition state very closely.

Accepted Answer

Transition-state analogs are compounds that mimic the chemical and structural characteristics of the transition state of a reaction. They are stable molecules that can bind to the active site of an enzyme with high affinity, but do not undergo catalysis. Therefore, they can be used as inhibitors to block the enzyme activity. Transition-state analogs are typically designed to resemble the transition state very closely, so they can be effective inhibitors.