Which of the Following Does the Amount of CAMP Generated

Question

Which of the following does the amount of cAMP generated in the cytoplasm depend upon?
A)the amount of PKA present
B)the activity of phospholipase C
C)the amount of ATP
D)the length of time the GTP remains bound to the Ga protein

Accepted Answer

The amount of cAMP generated in the cytoplasm depends on the length of time the GTP remains bound to the Ga protein. G proteins are activated when GDP is replaced by GTP, and the duration of this activation determines the amount of cAMP generated. Therefore, the length of time the GTP remains bound to the Ga protein is critical for cAMP synthesis. Choices A, B, and C are not directly related to cAMP synthesis.