Which of These Statements Regarding Phosphorylation of Acetyl-CoA Carboxylase Is

Question

Which of these statements regarding phosphorylation of acetyl-CoA carboxylase is correct?
A)Phosphorylation causes activation only in the presence of palmitoyl-CoA.
B)Phosphorylation is a result of insulin binding to its receptor.
C)High [citrate] inhibits the phosphorylated form.
D)Phosphorylation causes separation of the polymeric form of the enzyme to inactive protomers.

Accepted Answer

Phosphorylation of acetyl-CoA carboxylase leads to its inactivation by causing the enzyme to dissociate from its active polymeric form into inactive protomers. This regulatory mechanism is crucial for controlling the rate of fatty acid synthesis.