What Is/are the Main Source(s)of NADPH for Fatty Acid Biosynthesis

Question

What is/are the main source(s)of NADPH for fatty acid biosynthesis?
A)TCA cycle
B)oxidative phosphorylation
C)malic enzyme and the pentose phosphate pathway
D)glycolysis

Accepted Answer

Malic enzyme and the pentose phosphate pathway are the main sources of NADPH for fatty acid biosynthesis. The pentose phosphate pathway generates two molecules of NADPH per glucose-6-phosphate, while malic enzyme produces NADPH by oxidation of malate to pyruvate. Other pathways, such as the TCA cycle and glycolysis, do not produce significant amounts of NADPH for fatty acid biosynthesis. Oxidative phosphorylation produces ATP and NADH, but not NADPH.