Why is the three-dimensional shape of a protein important for its function?

A) It cannot function as a chromosome if it doesn't have the correct shape.
B) Shape determines how it functions and binds to other molecules.
C) An incorrectly shaped protein can't be made in translation.
D) If it isn't shaped correctly, it cannot leave the nucleus after translation.
E) Proteins contain the genetic information of the cell in their three-dimensional shape.